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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
22.42
Human Site:
S140
Identified Species:
49.33
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
L68
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
E139
P
W
T
F
L
V
R
E
S
L
S
Q
P
G
D
Dog
Lupus familis
XP_534686
571
65327
E128
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Rat
Rattus norvegicus
P41499
597
68440
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
Chicken
Gallus gallus
Q90687
593
67964
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Frog
Xenopus laevis
NP_001084076
595
68232
S140
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
S139
G
S
F
L
V
R
E
S
Q
S
K
P
G
D
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
E90
E
G
R
N
Q
L
K
E
R
N
G
Q
M
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
13.3
0
13.3
N.A.
100
100
N.A.
0
100
100
N.A.
N.A.
93.3
N.A.
N.A.
0
P-Site Similarity:
100
13.3
6.6
33.3
N.A.
100
100
N.A.
0
100
100
N.A.
N.A.
93.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
64
19
% D
% Glu:
19
0
10
0
0
0
55
28
0
0
0
0
0
0
10
% E
% Phe:
0
0
55
10
0
10
0
0
0
0
0
0
0
0
64
% F
% Gly:
55
10
0
10
0
0
0
0
0
10
10
0
73
10
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
46
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
0
0
10
0
0
10
0
10
0
19
0
0
0
0
% K
% Leu:
0
0
0
55
19
19
0
10
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
10
0
10
0
0
0
0
0
0
0
0
55
10
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
55
0
0
19
0
0
0
% Q
% Arg:
0
0
10
0
0
55
10
0
10
0
10
0
0
0
0
% R
% Ser:
10
55
0
0
0
0
0
55
19
55
10
0
0
10
0
% S
% Thr:
0
0
10
0
0
0
10
0
0
0
0
10
0
0
0
% T
% Val:
0
0
0
0
55
10
10
0
0
10
0
0
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _